Richard Janissen

PUBLICATIONS

* joint first authorship      ° corresponding authorship

R Janissen*, R Barth*, I F Davidson, J-M Peters, C Dekker°.
All eukaryotic SMC proteins induce a twist of -0.6 at each DNA-loop-extrusion step.
Science Advances, 10(50): eadt1832 (2024) 

I F Davidson, R Barth, S Horn, R Janissen, K Nagasaka, G Wutz, R R Stocsits, B Bauer, C Dekker, J-M Peters°.
Cohesin supercoils DNA during loop extrusion.
bioRxiv – DOI: 10.1101/2024.03.22.586228 (2024) 

AM Gonzalez*, M Tisma*, BT Analikwu, A Barth, R Janissen, H Antar, G Kemps, S Gruber, C Dekker°.
DNA supercoiling enhances DNA condensation by ParB proteins.
Nucleic Acids Research, 52(21):13255 (2024)

R Janissen, R Barth, M Polinder, J van der Torre, C Dekker°.
Single-molecule visualization of twin-supercoiled domains generated during transcription.
Nucleic Acids Research, 52(4):1677 (2023) 

M Tišma, R Janissen, H Antar, AM Gonzalez, R Barth, T Beekman, J vd Torre, D Michieletto, S Gruber, C Dekker°.
Dynamic ParB-DNA interactions initiate and maintain a partition condensate for bacterial chromosome segregation.
Nucleic Acids Research, 51(21):11856 (2023)

IF Davidson*, R Barth*, M Zaczek*, J van der Torre, W Tang, K Nagasaje, R Janissen, J Kerssemakers, G Wutz, C Dekker°, JP Peters°.
CTCF is a DNA-tension-dependent barrier to cohesin-mediated DNA loop extrusion.
Nature, 616:822 (2023)

R. Janissen, G.A. Filonenko°.
Mechanochemistry of Spiropyran Under Internal Stresses of a Glassy Polymer.
JACS – Journal of American Chemical Society, 144(50): 23198 (2022)

L. Kuijpers, T. van Laar, R. Janissen°, N.H. Dekker°.
Characterizing Single-Molecule Dynamics of Viral RNA-Dependent RNA Polymerases with Multiplexed Magnetic Tweezers.
Cell Press STAR Protocols, 3(6): 101606 (2022)

R. Janissen*, J.-K. Ryu*, S.-H. Rah*, J.W.J. Kerssemakers*, A. Bonato, D. Michieletto, C. Dekker°.
Condensin extrudes DNA loops in steps up to hundreds of base pairs that are generated by ATP binding events.
Nucleic Acids Research 50(2):gkab1268 (2022)

R. Janissen*, B. Eslami-Mossallam*, I. Artsimovitch°, M. Depken°, N.H. Dekker°.
High-throughput single-molecule experiments reveal heterogeneity, state switching, and three interconnected pause states in transcription.
Cell Reports, 39(4): 110749 (2022)

R. Janissen*, A. Woodman*, D. Shengjuler, T. Vallet, K.-M. Lee, I. Moustafa, F. Fitzgerald, P.-N. Huang, L. Kuijpers, A.L. Perkins, D.A. Harki, J.J. Arnold, B. Solano, S.-R. Shih, M. Vignuzzi°, C.E. Cameron°, N.H. Dekker°.
Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses. 
Molecular Cell, 81(21):5567 (2021) 

B.A.E. Lehner, D. Benz, S.A. Moshkalev, A.S. Meyer, M.A. Cotta ,R. Janissen°.
Biocompatible Graphene Oxide Nanosheets Densely Functionalized with Biologically Active Molecules for Biomedical Applications.
ACS Applied Nano Materials, 4(8):8334 (2021)

L. Liang*, K. Ma*, Z. Wang, R. Janissen°, Z. Yu°.
Dynamics and Inhibition of MLL1 CXXC Domain on DNA Revealed by Single-Molecule Quantification.
Biophys. J., 120(16):3235 (2021)

S. Anbumani, A.M. da Silva, E.R Fisher, M de Souza e Silva, A.A.G. von Zuben, H.F. Carvalho, A.A. de Souza, R. Janissen°, M.A Cotta°.
Controlled spatial organization of bacterial growth reveals key role of cell filamentation preceding Xylella fastidiosa biofilm formation.
Nature npj Biofilms and Microbiomes 7(86) (2021)

S. Ha*, Y. Tang*, M.M. van Oene, R. Janissen, R. Dries, B. Solano, A.J.L. Adam°, N.H. Dekker°.
Highly birefringent Titania Nanocylinders provide exceptional Optical Torque transfer efficiency.
ACS Photonics, 6(5):1255 (2019)

A. Woodman, K.-M. Lee, R. Janissen, Y.-N. Gong, N.H. Dekker, S,-R. Shih, C.E. Cameron°.
Predicting intraserotypic recombination in Enterovirus 71.
J. Virology, 93:e02057-18 (2019)

R. Janissen*, M. Ahrens*, N. Vtyurina*, Z. Rivai, N.D. Sunday, B. Eslami-Mossallam, A.A. Gritsenko, L. Laan, D. de Ridder, I. Artsimovitch, N.H. Dekker°, E. Abbondanzieri°, A.S. Meyer°.  Global DNA Compaction in Stationary-Phase Bacteria Does Not Affect Transcription.
Cell, 174(5):1188 (2018)

A.M. da Silva, P.K. Sahoo, A. Cavalli, A.A. de Souza, E.P.A.M. Bakkers, C.L. Cesar, R. Janissen°, M. Cotta°.
Nanowire Cell Force Sensor: Nanowire Arrays as Force Sensors with Super-Resolved Localization Position Detection
Small, 2(7):1700411 (2018)

R. Janissen*°, P.K. Sahoo*, C.A. Santos, A.M. da Silva, A.A.G. von Zuben, D.E.P. Souto, A.D.T. Costa, P. Celedon, N.I.T. Zanchin, D.B. Almeida, D.S. Oliveira, L.T. Kubota, C.L. Cesar, A.P. de Souza, M. A. Cotta°.
InP nanowire biosensor with tailored biofunctionalization: ultrasensitive and highly selective disease biomarker detection.
Nano Letters, 17(10):5938 (2017)

P.K. Sahoo, R. Janissen, A. Das, D. Inbakandan, P.S. Murthy°.
Nanoparticulates and Nanocomposites as Antibiofilm Agents: Evolving Perspectives.
Biofilms in Environment: Process Application and its Control, Narosa Publishing (2017)

P.K. Sahoo, R. Janissen, M.P. Monteiro, A. Cavalli, D.M. Murillo, M.V Merfa, C.L. Cesar, H.F. Carvalho, A.A. de Souza, E.P. Bakkers°, M.A. Cotta°.
Nanowire Arrays as Cell Force Sensors to Investigate Adhesin-Enhanced Holdfast of Single Cell Bacteria and Biofilm Stability.
Nano Letters, 16(7):4656 (2016)

R. Janissen*, D.M. Murillo*, B. Niza, P.K. Sahoo, M.P. Monteiro, C.L. Cesar, H.F. Carvalho, A.A. Souza, M.A. Cotta°.
Filamentation and Spatiotemporal Distribution of Extracellular Polymeric Substances: Role on X. Fastidiosa Single Cell Adhesion and Biofilm Formation.
Proceedings SPIE 97110H (2016)

S. Ha, R. Janissen, Y.Y. Ussembayev, M.M. van Oene, N.H. Dekker°.
Tunable top-down fabrication and functional surface coating of single-crystal titanium dioxide nanostructures and nanoparticles.
Nanoscale 8(20):10739 (2016)

E. Ostrofet, S. Ha, R. Janissen, T. van Laar, N.H. Dekker°.
Stretched Oriented DNA Arrays (SODA) as a Tool for Studying Protein-DNA Interactions.
Biophys. J. 3(110):166 (2016)

B.A. Berghuis, D. Dulin, Z. Qiang Xu, T. van Laar, B. Cross, R. Janissen, S. Jergic, N.E. Dixon°, S.M. Depken°, N.H. Dekker°.
Strand separation suffices to establish a long-lived, foolproof DNA-protein lock at the Tus-Ter replication fork barrier.
Nature Chemical Biology, 11:579-585 (2015)

R. Janissen*, D.M. Murillo*, B. Niza, P.K. Sahoo, M.M. Nobrega, C.L. Cesar, M.L.A. Temperini, H.E. Carvalho, A.A. Souza, M.A. Cotta.
Spatiotemporal distribution of different exopolysaccharides and filamentation mediate Xylella fastidiosa adhesion and biofilm formation.
Scientific Reports 5:9856 (2015)

C.A. Santos, R. Janissen, M.A.S. Toledo, L.L. Beloti, A.R. Azzoni, M.A. Cotta, R. Aparicio°, A P. Souza°.
Characterization of the TolB-Pal Trans-Envelope Complex from Xylella fastidiosa Reveals a Coordinated Protein Expression Profile during the Biofilm Development Process.
Biochimica Biophysica Acta 10.1016/j.bbapap.2015.05.018 (2015)

D.M. Murillo, R. Janissen, B. Niza, P.K. Sahoo, M.M. Nobrega, C.L.Cesar, M.L.A. Temperini, H.F. Carvalho, A.A. Souza, M.A. Cotta°.
Investigation n Xylella Fastidiosa Biofilms: From Single Cell Adhesion to Mature Architecture.
Europ. Biophys. J. Biophys. Letters 44:S81 (2015)

R. Janissen, B.A. Berghuis, D. Dulin, M. Wink, T. van Laar, N.H. Dekker°.
Invincible DNA tethers: covalent DNA anchoring for enhanced temporal and force stability in magnetic tweezers experiments.
Nucleic Acids Research, doi: 10.1093/nar/gku677 (2014)

M.T. Favaro, M.A. de Toledo, R.F. Alves, C.A. Santos, L.L. Beloti, R. Janissen, L.G. de la Torre, A.P. Souza°, A.R. Azzoni°.
Development of a non-viral gene delivery vector based on the dynein light chain Rp3 and the TAT peptide.
Journal of Biotechnology, 173:10 (2014)

R. Janissen, B.A. Berghuis, O. Ordu, M.M Wink, D. Dulin, J.P. Cnossen, N.H. Dekker°.
Single Molecule Studies of DNA-Binding Proteins: Development of New Covalent DNA Anchoring Techniques for the Study of Rupture Forces of Replication Blocks.
Biophys. J. 106(2):394 (2014)

G.S. Lorite, R. Janissen, J.H. Clerici, C.M. Rodrigues, J.P. Tomaz, B. Mizaikoff, C. Kranz, A.A. de Souza°, M.A. Cotta°.
Surface physicochemical properties at the micro and nano length scales: role on bacterial adhesion and Xylella fastidiosa biofilm development.
PLoS One 8(9):e75247 (2013)

M. Jager*, C. Boge*, R. Janissen, D. Rohrbeck, T. Hulsen, S. Lensing-Hohn, R. Krauspe, M. Herten°.
Osteoblastic potency of bone marrow cells cultivated on functionalized biometals with cyclic RGD-peptide.
Journal of Biomedical Material Research A 101(10):2905 (2013)

M.T.P. Favaro, M.S. Toledo, R.F. Alves, R. Janissen, A.P. Souza, A.R. Azzoni°.
Engineered dynein light chain Rp3: a strategy to exploit cell’s machinery for an enhanced intracellular trafficking of transgenes.
Human Gene Therapy 24(12):A63 (2013)

R. Janissen*, A. L. Moreau*, C. A. Santos, L. A. Peroni, D. R. Stach-Machado, A. A. de Souza, A. P. de Souza, M. A. Cotta°.
Highly-sensitive and label-free indium phosphide biosensor for early phytopathogen diagnosis.
Biosensors and Bioelectronics 36(1):62 (2012)

M. A. Toledo, R. Janissen, M. T. Favaro, M. A. Cotta, G. A. Monteiro, D. M. Prazeres, A. P. de Souza, A. R. Azzoni.
Development of a recombinant fusion protein based on the dynein light chain LC8 for non-viral gene delivery.
Journal of Controlled Release 159(2):222 (2012)

P.J. Rothwell, W.J. Allen, E. Sisamakis, R. Janissen, S. Kalinin, S. Felekyan, J. Widengren°, G. Waksman°, C.A.M. Seidel°.
dNTP-Dependent Conformational Transitions in the Finger Subdomain of Klentaq1.
Biophysical J., 100(3):376 (2011)

R. Janissen, F. Oesterhelt°.
Directed deposition of single molecules on surfaces.
Journal of Nanoscience and Nanotechnology 10(8):5328 (2010)

R. Janissen°.
Nano meets Bio – Techniques for biomolecule manipulation on single-molecule level.
SVH-Verlag. ISBN 978-3-8381-1708-9 (2010)

L. Oberbarnscheidt*, R. Janissen*, F. Oesterhelt°.
Direct and model free calculation of force-dependent dissociation rates from force spectroscopic data.
Biophysical J., 97(9):L19 (2009)

R. Janissen, L. Oberbarnscheidt, F. Oesterhelt°.
Optimized straight forward procedure for covalent surface immobilization of different biomolecules for single molecule applications.
Journal of Colloids and Surfaces B: Biointerfaces 71(2):200 (2009)

L. Oberbarnscheidt, R. Janissen, S. Martell, M. Engelhard°, F. Oesterhelt°.
Single-molecule force spectroscopy measures structural changes induced by light activation and transducer binding in sensory rhodopsin II.
J Mol Biol. 394(3):383 (2009)